Liquid chromatography-mass spectrometry-based metabolomics study of the protective mechanism of Shenji Guben decoction on chronic obstructive pulmonary disease.

ABSTRACT:

Objective

To investigate the mechanisms of the effect of Shenji Guben (SJGB) decoction on chronic obstructive pulmonary disease (COPD).

Methods

A murine model of COPD was established through lipopolysaccharide (LPS) nasal drops and passive smoke exposure, followed by evaluation of SJGB decoction efficacy via lung function tests and histological analysis. Non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics was used to explore the mechanisms of SJGB decoction in COPD.

Results

We found that the SJGB decoction effectively reduced inflammatory cell infiltration in the airways and lungs, and improved lung function in the COPD model mice. LC-MS-based metabolomics identified 86 biomarkers in COPD models. Compared to the model group, SJGB dec

SUBMITTER: Tingyu P 

PROVIDER: S-EPMC12453992 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature