NUFIP1-Mediated Ribophagy Alleviates PANoptosis of CD4⁺ T Lymphocytes in Sepsis via the cGAS-STING Pathway.

ABSTRACT: T lymphocyte dysfunction represents a pivotal determinant of immunosuppression in sepsis. Our previous studies demonstrated that nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)-mediated ribophagy conferred cytoprotection against apoptosis in CD4⁺ T lymphocytes during sepsis, thereby preserving host immunocompetence. Despite growing evidence linking PANoptosis to the pathogenesis of various diseases, the potential role of ribophagy in modulating CD4⁺ T lymphocytes' PANoptosis in sepsis remains largely unclear. In the present study, we employed both lipopolysaccharide-stimulated Jurkat T cells and cecal ligation and puncture (CLP)-induced sepsis models to demonstrate marked exacerbation of CD4⁺ T lymphocyte PANoptosis following NUFIP1</

SUBMITTER: Zhao P 

PROVIDER: S-EPMC12454940 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature