Interleukin-10 limits immune-mediated pathology in chronic subclinical plasmodial infection.

ABSTRACT: Subclinical parasitemia constitutes the predominant proportion of Plasmodium spp. infections in hyperendemic regions of the world. Elevated levels of serum interleukin-10 (IL-10) are observed in both acute symptomatic and chronic subclinical Plasmodium spp. infections. The role of IL-10 in acute infection has been extensively studied; however, the role of sustained elevated levels of IL-10 in chronic subclinical plasmodial infections remains to be determined. We investigated the role of IL-10 in a long-term subclinical and patent Plasmodium chabaudi chabaudi-AS (Pc) infection using mice lacking humoral immunity (µMT-/- mice). Pc-infected µMT-/- mice exhibit a long-term (99 days) chronic infection, with microscopic levels of parasitemia and without any outward signs of disease. We found tha

SUBMITTER: de Souza Silva L 

PROVIDER: S-EPMC12463326 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature