Dataset Information
A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals.
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ABSTRACT:
SUBMITTER: Kakar A
PROVIDER: S-EPMC12465664 | biostudies-literature | 2025 Sep
REPOSITORIES: biostudies-literature
Publications
A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals.
BMC nephrology 20250926 1
BACKGROUND: Hypertension (HT) and chronic kidney diseases (CKD) are complex conditions having both genetic and environmental contributions, disproportionately affecting African American (AA) individuals. Recent evidence is contradictory regarding the directionality of the relationship between the two conditions. This study investigates the relationship between CKD and blood pressure (BP)-related traits with CKD and BP by generating polygenic risk scores (PRSs) for CKD and BP-related traits in 2, ...[more]
