Molecular Epidemiology of <i>tet</i>(A)-v1-Positive Carbapenem-Resistant <i>Klebsiella pneumoniae</i> in Pediatric Patients in a Chinese Hospital.

ABSTRACT: Background: The emergence and spread of the tigecycline resistance gene tet(A)-v1 in carbapenem-resistant Klebsiella pneumoniae (CRKP) poses significant public health challenges. However, the prevalence of tet(A)-v1-positive CRKP, especially in pediatric patients, remains poorly understood. This study aims to address the gap by performing an in-depth analysis of isolates collected from a children's hospital in China. Methods: A 4-year retrospective study was conducted in the children's hospital in Suzhou, China. Non-duplicated specimens were obtained from pediatric patients, and antimicrobial susceptibility profiles were assessed. Whole-genome sequencing and bioinformatics analyses were conducted to characterize the genetic background, antimicrobial resis

SUBMITTER: Xu C 

PROVIDER: S-EPMC12466384 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature