Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake.

ABSTRACT:

Purpose

Dopaminergic dysregulation plays a critical role in myopia development in animal models. Although its relevance to human myopia remains uncertain, the observation that methylphenidate hydrochloride (MPH)-a dopamine (DA) and norepinephrine (NE) uptake inhibitor-slows myopia progression in children suggests a possible link. This study aimed to investigate whether MPH can inhibit myopic growth and elucidate the underlying mechanisms using an animal model.

Methods

MPH was administered via oral, topical, or intravitreal routes for 7 days (minimum 5 per group) to chicks undergoing form-deprivation myopia (FDM). Myopia was assessed by refraction and axial length. Retinal DA and NE dynamics-including synthesis, release, uptake, breakdown (DA only), extracellular levels, and

SUBMITTER: Karouta C 

PROVIDER: S-EPMC12468103 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature