Concave-Octahedral Fe²⁺-Rich Fe-MOF/FU Nano-Blocks with Enhanced pH-Responsive Nanozyme Activity Toward Stimuli-Responsive Gels for Chemo-Chemodynamic Synergistic Therapy.

ABSTRACT: Hydroxyl radicals (·OH) offer exceptional potential for cancer treatment through reactive oxygen species (ROS) amplification and apoptotic induction. However, conventional Fe-based metal-organic framework (Fe-MOF) nanomaterials are limited by inadequate Fe²⁺ concentrations, resulting in suboptimal Fenton catalytic performance. This study presents concave octahedral Fe-MOF nanomaterials with integrated bimetallic Fe/Zn centers through controlled solvothermal synthesis. The nanoplatform exhibits high specific surface area (559 m²/g) and 5-fluorouracil (5-FU) loading efficiency (58.7%). These structural properties establish it as a potential nanobuilding block for constructing stimuli-responsive gels. With optimized Fe²⁺ content (57.3%), the Fe-MOF material sh

SUBMITTER: Wang D 

PROVIDER: S-EPMC12469758 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature