<i>Mycoplasma bovis</i> Infection Induces Apoptosis Through Gadd45/XIAP in Bovine Macrophages.

ABSTRACT: Mycoplasma bovis (M. bovis) adheres to host cells and persists intracellularly, causing chronic inflammation and significant economic losses in the cattle industry. The role of host cell apoptosis in this host-pathogen interaction remains unclear. This study isolated and identified the M. bovis Xinjiang strain XJ01 from diseased cattle in China. XJ01 exhibited typical "fried egg" colony morphology, distinct biochemical characteristics, and a 1.02 Mb genome (29.33% GC content) encoding 939 genes, including 93 unique genes. Functional analysis under optimal infection conditions (MOI = 1000, 24 h) revealed that XJ01 induced significant apoptosis and reduced viability in bovine macrophages (BoMac). This was accompanied by mitochondrial homeostasis disruption, characterized

SUBMITTER: Li R 

PROVIDER: S-EPMC12472996 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature