Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population.

ABSTRACT:

Introduction

Chronic emotional stress is a well-recognized risk factor for psychiatric and cardiometabolic disorders. The mediating role of low-grade inflammation in older, ethnically diverse populations has never been studied.

Methods

The multiethnic ≥50-year-old study population is a subset of the Health and Aging Brain Study: Health Disparities (HABS-HD) study. Adjusted logistic and linear regression were used to assess associations. Statistical mediation analysis with non-parametric bootstrapping of confidence intervals was used to determine the intermediate role of Interleukin-6 (IL-6).

Results

The study included 2173 participants (50-92 years). Black participants disclosed higher chronic stress levels than White and Hispanic participants. Having a chronic stress

SUBMITTER: Hallab A 

PROVIDER: S-EPMC12475582 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature