Metabolomic Profiles of Oral Rinse Samples to Distinguish Severe Periodontitis Patients From Non-Periodontitis Controls.

ABSTRACT:

Aims

To explore the potential of metabolomic profiles of oral rinse samples to distinguish between patients with severe periodontitis (stage III/IV) and non-periodontitis controls. This is coupled to an analysis of differences in metabolomic profiles between individuals without periodontitis, patients with localized periodontitis, and patients with generalized periodontitis.

Methods

Periodontitis patients and controls were recruited, all aged ≥ 40 years. Study participants were asked to rinse vigorously for 30 s with 10 mL phosphate buffered saline. Metabolites were identified using a semi-targeted liquid chromatography tandem mass spectrometry (LC-MS/MS) platform.

Results

In total, 38 periodontitis patients (18 localized, 20 generalized stage III/IV periodontitis pat

SUBMITTER: Kosho MXF 

PROVIDER: S-EPMC12476085 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature