Association of Gut Microbiota-Derived Short-Chain Fatty Acids With Persistent Elevated Serum Transaminase Levels in Normal Weight and Obesity: A Pilot Study.

ABSTRACT: Although obesity is the most common risk factor for hepatic steatosis, this disease may occur in normal-weight individuals. While gut microbial metabolites such as short-chain fatty acids (SCFAs) have been associated with obesity and metabolic disease, the relationship among fecal SCFA concentrations, SCFA-producing bacteria, and hepatic steatosis with and without obesity is not fully understood. This pilot study aimed to compare fecal SCFA concentrations and SCFA-producing gut bacteria in four study groups: 7 individuals with normal-weight and normal alanine aminotransferase levels (Nw-N ALT), 7 individuals with normal-weight and elevated ALT levels (Nw-E ALT), 12 individuals with obesity and normal ALT levels and (Ob-N ALT), and 18 individuals with obesity and elevated ALT levels (Ob-E A

SUBMITTER: Diaz de Sandy-Galan DA 

PROVIDER: S-EPMC12476282 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature