The e-BRAVE study: A prospective web-based cohort and biobank of women carriers of BRCA mutations.

ABSTRACT:

Background

Women carriers of BRCA1/2 mutations face a very high lifetime risk (penetrance) of developing breast and/or ovarian cancer. A sizeable proportion of carriers, however, does not develop cancer at all or develop it only late in life, thus suggesting a potential modulation of this risk. Epidemiological studies have suggested that other genetic (polymorphisms) and environmental factors (lifestyle) affect penetrance. However, data regarding these associations mainly come from retrospective case-control analyses and the results are likely to be distorted by bias.

Aims

The e-BRAVE (Brca, ReseArch, Virtual, Education) study aims to create a web-based prospective cohort and biological bank of unaffected women carriers of BRCA1/2 mutations to investigate the r

SUBMITTER: Oliverio A 

PROVIDER: S-EPMC12476487 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature