Impact of the type of bacteria on high-density lipoprotein cholesterol level during sepsis.

ABSTRACT: High-density lipoproteins (HDL) are nanoparticles that enable the reverse transport of cholesterol and have multiple endothelioprotective properties that may play a role in sepsis, where HDL-cholesterol (HDL-C) concentrations typically plummet, which is strongly linked to poor outcomes. While HDL has the capacity to capture and eliminate lipopolysaccharides (LPS), which may explain this decrease in HDL-C concentration, this effect is less clear for Gram-positive bacteria via binding to lipoteichoic acid (LTA). The aim of this study is to determine whether the type of bacteria influences HDL-C concentrations in septic patients. This was a prospective, observational, single-center study of septic patients hospitalized in the intensive care unit (ICU). Patients were stratified into three grou

SUBMITTER: De Tymowski C 

PROVIDER: S-EPMC12480970 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature