Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of <i>Salmonella</i> Enteritidis.

ABSTRACT:

Background

Salmonella Enteritidis (S. Enteritidis) is an important zoonotic pathogen that poses a major threat to animals and human health. TrxB, as a key component of the thioredoxin system, is a thioredoxin reductase ubiquitously present in organisms. It is mainly involved in maintaining cellular redox balance, but its role in the pathogenicity of S. Enteritidis remains unclear.

Methods

In this study, we generated a trxB-deficient strain from S. Enteritidis C50336 strain to investigate how TrxB affects the biological characteristics and pathogenesis of the bacterium. The virulence of ΔtrxB was assessed by measuring ΔtrxB resistance to environmental stress, biofilm formation ability, motility, adhesion, invasion ability, intr

SUBMITTER: Zhu S 

PROVIDER: S-EPMC12484166 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature