Outdoor Air Pollution, Perivascular Space Morphology, and Cognition in Preadolescence.

ABSTRACT:

Background

Ambient air pollution exposure is associated with structural brain differences and poorer cognition in children; however, mechanisms of toxicity remain unclear. Perivascular spaces (PVS), key for brain waste clearance, may play a role in the neurotoxicity of air pollution. This study explored associations between air pollution exposure, PVS morphology, and cognition in preadolescents.

Methods

We analyzed cross-sectional Adolescent Brain Cognitive Development^SM (ABCD) Study^® data from 6,949 9-10-year-old participants. Annual average exposures to PM_2.5, O₃, NO₂, and 15 PM_2.5 components were estimated using spatiotemporal models mapped to residential addresses. PVS count and volume were derived from T1

SUBMITTER: Morrel J 

PROVIDER: S-EPMC12485759 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature