Autoimmune nodopathy with anti-NF186 antibodies following SARS-CoV-2 infection: a case report.

ABSTRACT:

Background

Autoimmune nodopathy is a distinct entity characterized by antibodies targeting nodal/paranodal proteins like neurofascin-186 (NF186), leading to conduction defects and neurological dysfunction. This report highlights a unique case of autoimmune nodopathy with anti-NF186 antibodies following SARS-CoV-2 infection.

Case presentation

A 47-year-old female developed acute limb numbness and weakness ten days post-COVID-19 diagnosis, which progressed to respiratory muscle paralysis necessitating mechanical ventilation. Initial treatments with intravenous immunoglobulin and steroids were ineffective. Diagnosis of autoimmune nodopathy with anti-NF186 antibodies was confirmed through clinical examination, electromyography (EMG), and serum antibody testing using cell-based a

SUBMITTER: Lai J 

PROVIDER: S-EPMC12486672 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature