MAOA haplotypes associated with thrombocyte-MAO activity.

ABSTRACT:

Background

The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals).

Results

Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as two distinct LD blocks. We found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state.

Conclusion

The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-

SUBMITTER: Jansson M 

PROVIDER: S-EPMC1249565 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature