Regional tau PET patterns predict prospective domain-specific cognitive decline in early symptomatic Alzheimer's disease.

ABSTRACT:

Background

Tau-PET binding patterns are heterogenous, with regional binding showing strong cross-sectional correlations with domain-specific cognitive performance and longitudinal correlations with prospective neurodegeneration. Here we evaluated whether regional patterns of baseline tau-PET predict prospective longitudinal decline in specific cognitive domains in early symptomatic Alzheimer's disease (AD), including participants from clinical trial cohorts.

Methods

731 amyloid-positive participants with a clinical diagnosis of mild cognitive impairment (MCI) or mild AD dementia underwent a flortaucipir F 18 PET (FTP-PET), structural MRI, and neuropsychological testing with the AD Assessment Scale-Cognitive Subscale (ADAS-Cog). Cognitive assessment was repeated after 9-18 or

SUBMITTER: Malpetti M 

PROVIDER: S-EPMC12502172 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature