Visually Identified Tau 18F-MK6240 PET Patterns in Symptomatic Alzheimer's Disease.

ABSTRACT:

Background

In Alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in vivo may facilitate clinical trials and clinical practice.

Objective

This study aimed to investigate whether tau distribution patterns that are limited to mesial temporal lobe (MTL)/limbic regions, and those that spare MTL regions, can be visually identified using 18F-MK6240, and whether these patterns are associated with different demographic and cognitive profiles.

Methods

Tau 18F-MK6240 PET images of 151 amyloid-β positive participants with mild cognitive impairment (MCI) and dementia were visually rated as: tau negative, limbic predominant (LP), MTL-sparing, and Typical by two readers. Groups were ev

SUBMITTER: Krishnadas N 

PROVIDER: S-EPMC9484111 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature