Zinc deficiency predicts new-onset diabetic kidney disease in type 2 diabetes: a retrospective cohort study.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is a major global health challenge, with diabetic kidney disease (DKD) representing one of its most serious complications. Although zinc deficiency is common in diabetes, large-scale clinical evidence on its role as a predictor of new-onset DKD is limited.

Methods

We conducted a retrospective cohort study using the TriNetX Analytics Network Platform to analyze patients aged ≥18 years who underwent zinc testing (2010-2023). Patients were classified into zinc deficiency (serum zinc <70 μg/dL) and control groups (70-120 μg/dL). After 1:1 propensity score matching, we analyzed the risk of new-onset DKD at two-year follow-up. The secondary outcomes included the risks of all-cause mortality, acute kidney injury (AKI), chronic kidney disea

SUBMITTER: Hung KC 

PROVIDER: S-EPMC12504847 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature