Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD.

ABSTRACT:

Background

IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models often fail to fully recapitulate all aspects of the human disease. A systematic comparison of commonly used IBD models is essential to identify conserved molecular mechanisms and improve translational relevance.

Objective

We performed a multimodel transcriptomic analysis of 13 widely used IBD mouse models to uncover coregulatory gene networks conserved between preclinical colitis/ileitis and human IBD and to define model-specific and conserved cellular, subcellular and molecular signatures.

Design

We employed comparative transcriptomic analyses with curated and a priori statistical correlative methods between mouse models versus IBD patient data

SUBMITTER: Gonzalez-Acera M 

PROVIDER: S-EPMC12505074 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature