Cribriform pattern and IDC-P in prostate biopsies: prognostic relevance and reporting in metastatic disease.

ABSTRACT: Cribriform pattern and intraductal carcinoma of the prostate are recognized adverse histological features, yet their prognostic value in treatment-naïve metastatic disease remains uncertain. We conducted a single-center retrospective study of 183 biopsy-proven prostate carcinomas (105 with metastatic castration-sensitive prostate carcinoma and 78 non-metastatic high-grade cases) diagnosed between 2017 and 2024. Cribriform pattern, intraductal carcinoma of the prostate, and coagulative tumor necrosis were recorded per core and summarized as patient-level binary status and as semiquantitative proportions per cancer-positive core. Two multivariable logistic regression models (binary and semiquantitative) were fitted, and receiver operating characteristic (ROC) analysis evaluated the discrimin

SUBMITTER: Okubo Y 

PROVIDER: S-EPMC12508520 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature