Gamma sensory stimulation in mild Alzheimer's dementia: An open-label extension study.

ABSTRACT:

Introduction

We evaluated the long-term effects of daily 40 Hz (gamma frequency) audiovisual stimulation on cognition and biomarkers in five patients with mild Alzheimer's disease (AD).

Methods

Over 2 years, patients received 1-h daily stimulation. Electroencephalography (EEG) was used to assess neural entrainment; magnetic resonance imaging (MRI) measured brain volumes; actigraphy monitored activity patterns; neuropsychological tests evaluated cognition; and S-PLEX assay measured plasma pTau217.

Results

No adverse events occurred over the study period. Three female patients with late-onset AD (LOAD) retained strong EEG entrainment and showed less decline in Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Functional Assessment Scale (FAS) sco

SUBMITTER: Chan D 

PROVIDER: S-EPMC12552893 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature