Integrated genomic and proteomic analysis of the mouse-adapted <i>Staphylococcus aureus</i> strain JSNZ.

ABSTRACT: Mouse-adapted Staphylococcus aureus strains have become increasingly relevant in infection research thanks to their ability to better recapitulate clinical infection dynamics in mouse models. However, detailed characterisations required to establish a corresponding reference strain are still lacking. The mouse-adapted CC88 strain JSNZ appears to be an ideal candidate for a reference strain. Here, we present a comprehensive genomic and proteomic characterisation of JSNZ. Whole genome sequencing was performed using a combination of short and long reads. Proteomic profiling was conducted under standard laboratory conditions in TSB and RPMI during exponential and stationary growth using LC-MS/MS. The updated, closed genome sequence of JSNZ was integrated into AureoWiki for user-f

SUBMITTER: Wolfgramm H 

PROVIDER: S-EPMC12554148 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature