Comprehensive analysis of cuproptosis-related genes in diabetic cardiomyopathy.

ABSTRACT:

Background

Diabetic cardiomyopathy (DCM) represents a distinct myocardial pathology arising from chronic diabetic metabolic disturbances, characterized by progressive structural and functional abnormalities that frequently culminate in heart failure. Cuproptosis, a novel form of cell death, is highly linked to mitochondrial metabolism and mediated by protein lipoylation. However, studies are limited on the clinical significance of cuproptosis-related genes (CRGs) in DCM. Therefore, it is helpful to identify CRGs involved in DCM and explore their expression and molecular mechanisms.

Methods

We downloaded three datasets of DCM from the GEO database and a set of cuproptosis-related genes with 176 genes. Following the identification of the differentially expressed cuproptosis-re

SUBMITTER: Li J 

PROVIDER: S-EPMC12558461 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature