Cytotoxic Triterpene Glycosides from Mexican Sea Cucumber <i>Holothuria inornata</i>.

ABSTRACT: Sea cucumbers (Holothuriidae) are highly valued in traditional medicine and are recognized for their diverse bioactivities, which are largely attributed to their rich triterpene glycoside content. Given that Holothuria inornata was chemically uncharacterized, this study describes the bioassay-guided isolation of these compounds. Nine sulfated saponins were purified, and their structures were elucidated using UPLC-QTOF/HR-ESI-MSⁿ and comprehensive NMR spectroscopy. Six new compounds were identified, including inornatosides A-C (1-3) and 22R-holothurin B (6), all possessing a holostane-type aglycone, alongside inornatosides D (4) and E (5), which feature unique aglycones. Cytotoxic assays revealed that inornatoside B (2

SUBMITTER: Lopez-Sampedro E 

PROVIDER: S-EPMC12560079 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature