Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNA.

ABSTRACT: RNA-binding proteins regulate post-transcriptional gene translation, but the macrophage-specific role of Zc3h12c remains poorly characterized. Here, the role of Zc3h12c in macrophages is characterized using Tnfrsf11a^Cre-Zc3h12c^flox/flox mice. Both Tnfrsf11a and Zc3h12c are highly expressed in the kidney tissue from patients with chronic kidney disease and showed a positive association with an interstitial fibrosis score. Single cell RNA sequencing demonstrated abundant Tnfrsf11a expression in murine kidney macrophages and a correlation with the induction of chemokines, macrophage phagocytosis, and activation upon kidney injury. In various kidney injury models, Tnfrsf11a^Cre-Zc3h12c^flox/flox mice suffered from more injury and inflammation in the ki

SUBMITTER: Li C 

PROVIDER: S-EPMC12561471 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature