Analysis of the TGF-β1 of a Tibetan Plateau <i>Schizothoracine</i> Fish (<i>Gymnocypris dobula</i>) Revealed Enhanced Cytoprotection in Hypoxic Environments.

ABSTRACT: Background: The Tibetan Plateau, which is known for its high elevation and low oxygen levels, presents a challenging environment for its inhabitants. To adapt to these hypoxic conditions, species of Schizothoracine, a subfamily of Cyprinidae, have developed unique physiological mechanisms and functions. Transforming growth factor-β (TGF-β) is a multifunctional cytokine involved in the regulation of cell growth, differentiation, apoptosis, and the cellular immune response. However, its specific role in adaptation to hypoxia remains poorly understood. Methods: In this study, we aimed to characterize the TGF-β1 gene in Gymnocypris dobula (Gd) and Schizothorax prenanti (Sp) and to test whether TGF-β1 contributes to hypoxia adaptation in p

SUBMITTER: Le Z 

PROVIDER: S-EPMC12562280 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature