Resin Glycosides with <i>α</i>-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activities from the Seeds of <i>Cuscuta japonica</i>.

ABSTRACT: In the present study, seven previously undescribed resin glycosides, designated cusponins I-VII (1-7), together with one known analog (8), were isolated from the seeds of Cuscuta japonica, a traditional medicine used in China. Structural elucidation revealed them to be glycosidic acid methyl esters, generated through on-column methyl esterification of naturally occurring resin glycosides catalyzed by NH₂-functionalized silica gel. All isolates were characterized as either pentasaccharides or tetrasaccharides, incorporating D-glucose, L-rhamnose, or D-fucose units as the sugar residues. Notably, compounds 1 and 3-7 contained the uncommon aglycone, 11S-hydroxypentadecanoic acid. Bioactivity assessments demonstrated that compo

SUBMITTER: Guo SP 

PROVIDER: S-EPMC12562854 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature