Metabolic profiling and pharmacological evaluation of alkaloids in three <i>Murraya</i> species.

ABSTRACT: This study comprehensively investigated the metabolic profiling, pharmacological potential, and biosynthetic regulation of alkaloids in three Murraya species (M. exotica, M. kwangsiensis, and M. tetramera). Through integrative multi-omics approaches, including metabolomics, transcriptomics, network pharmacology, and molecular docking, a total of 77 alkaloids were identified, categorized into 18 structural classes. Comparative analysis revealed species-specific accumulation patterns, with 50 alkaloids shared among all three species and unique metabolites detected in M. exotica and M. kwangsiensis. Principal component analysis (PCA) confirmed distinct alkaloid profiles, highlighting interspecies divergence. Network pharmacology identified 427 potenti

SUBMITTER: Huang H 

PROVIDER: S-EPMC12568637 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature