A Smart Triple-Signal Fluorescent Probe for Real-Time Differential Imaging of HClO, H₂O₂, and Their Mixture in Diabetic Models.

ABSTRACT: Diabetes is a complex metabolic disorder characterized by persistent hyperglycemia, which causes damage to multiple target organs and triggers a range of complications. Oxidative stress, driven by reactive oxygen species (ROS) such as hypochlorite (HClO) and hydrogen peroxide (H₂O₂), plays a crucial role in the onset and progression of diabetes and its associated complications. Therefore, the simultaneous and differential detection of HClO, H₂O₂, and their mixture is essential for accurately assessing oxidative stress status and understanding their synergistic roles in disease progression. In this study, we present a triple-signal fluorescent probe, probe 1, designed to simultaneously and selectively detect HClO, H₂O₂

SUBMITTER: Yu T 

PROVIDER: S-EPMC12569950 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature