Poly-L-Ornithine coated plant scaffolds support motor recovery in rats after traumatic spinal cord injury.

ABSTRACT: Spinal cord injury (SCI) is a debilitating neurological condition with far-reaching consequences for patients, including loss of motor function and significant limitations to quality of life. Implantable biomaterials have emerged as a therapeutic strategy to modulate the SCI microenvironment and facilitate regeneration of axons. In this study, plant-derived lignocellulosic scaffolds coated with poly-L-ornithine (PLO) are shown to support locomotor recovery and neural tissue repair in a rat model of spinal cord injury. Upon complete transection of the spinal cord, animals were implanted with a plant-derived scaffold coated in PLO, a positively charged amino acid chain that is known to promote neural stem cell differentiation into neurons and enhance myelin regeneration. Recovery of motor fu

SUBMITTER: Couvrette LJ 

PROVIDER: S-EPMC12575751 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature