Synthesis of morphologically diverse dual thermo- and pH-responsive nano-objects <i>via</i> RAFT-mediated emulsion PISA.

ABSTRACT: We report a versatile and efficient strategy for the synthesis of dual thermo- and pH-responsive polymeric nano-objects with rich morphological diversity, achieved via RAFT-mediated aqueous emulsion polymerization-induced self-assembly (PISA). Using a thermoresponsive poly(triethylene glycol methyl ether methacrylate) (PTEGMA) macro-chain transfer agent and a pH-sensitive diisopropylaminoethyl methacrylate (DPA) monomer, we generated PTEGMA-b-PDPA diblock copolymer nano-objects under conditions both below and above the LCST of PTEGMA. By systematically varying the length of the PDPA block, we accessed a wide array of morphologies-including micelles, worms, vesicles, and intricate "octopus"-like structures-simply by adjusting the polymerization temperature and hydrophobic bloc

SUBMITTER: Lukas Petrova S 

PROVIDER: S-EPMC12584748 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature