Three buffy coat platelet concentrates: Use of data modelling to make more with less.

ABSTRACT:

Background and objectives

The Welsh Blood Service (WBS) produces pooled platelet concentrates from four buffy coats (4BC-PC), achieving consistently high platelet yields exceeding the UK specification. Three buffy coat platelet concentrates (3BC-PC) offer the potential for improved supply chain resilience and increased production capacity. Data modelling was performed to evaluate the local feasibility of 3BC-PC production.

Materials and methods

Platelet recovery (%) was calculated from 41 4BC-PC to generate three reference values (maximum, average and minimum). Measurements from the 164 BCs were used to model 3BC-PC production, with further analysis determining the impacts of manufacturing variability. Calculated yields were assessed against UK, European (EU) and UK continge

SUBMITTER: Cahillane M 

PROVIDER: S-EPMC12602124 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature