Nuclear factor E2 p45-related factor (NRF2) and peroxiredoxin 6 tissular expression as prognostic biomarkers for advanced HPV-negative squamous cell carcinoma of the oropharynx.

ABSTRACT:

Objectives

Non-HPV-induced squamous cell carcinomas (SCC) of the oropharynx have a poorer prognosis than HPV-induced cancers because they are more radio- and chemoresistant. Currently, no predictive biomarker exists for survival outcome in this type of tumor. NRF2 is a nuclear transcription factor that regulates the expression of cytoprotective genes, and peroxiredoxin 6 is one of the proteins regulated by NRF2. Both are potentially involved in the resistance to treatments as they play a central role in the response to oxidative stress.

Material and methods

In a retrospective cohort study of 53 patients with advanced HPV-negative squamous cell carcinomas of the oropharynx, we studied the correlation between clinical characteristics, response to treatment (surgery + radiother

SUBMITTER: Philouze P 

PROVIDER: S-EPMC12630086 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature