Proteomic study of <i>Akkermansia muciniphila</i> and <i>Bifidobacterium</i> species co-culture under different carbon sources.

ABSTRACT: Akkermansia muciniphila and Bifidobacterium spp. are major probiotic strains that have been shown to improve host metabolism and treat metabolic diseases. Previous studies have proposed formulating these probiotics as a therapeutic product to improve efficacy, but how they affect the growth and protein expression of each other in response to different nutrient environments remains unexplored. Here, we performed label-free quantitative proteomics on A. muciniphila and two Bifidobacterium species, Bifidobacterium longum and Bifidobacterium breve, in the presence of different carbon sources. Akkermansia muciniphila displayed distinct growth profiles when co-cultured with B. breve and B. longum in media containing monosaccharides (

SUBMITTER: Sulaiman JE 

PROVIDER: S-EPMC12631272 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature