Multi-systemic risk of post-acute sequelae associated with SARS-CoV-2 reinfection.

ABSTRACT:

Background

Increased risk of post-acute sequelae was found to occur in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 reinfections). However, it is unclear whether these increases in post-acute risk are found in milder Omicron reinfections, or persist in a highly boosted population.

Methods

We utilised national COVID-19 databases and healthcare-claims records of Singapore to construct SARS-CoV-2 infected and uninfected cohorts over periods of Delta, Omicron BA.1/2, BA.4/5 and XBB predominance (1 July 2021-28 February 2023). The 300-day risk and excess burdens of pre-specified new-incident diagnoses across cardiovascular, neuropsychiatric, endocrine, auto-immune, renal, respiratory and gastrointestinal domains was compared across SARS-CoV-2 re-infected individual

SUBMITTER: Lim JT 

PROVIDER: S-EPMC12632001 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature