Clinical validation of a statin-benefit polygenic score using real-world cohorts of primary prevention participants.

ABSTRACT:

Background

Polygenic risk scores derived from coronary artery disease genome-wide association studies are associated with statin relative risk reduction.

Objective

Examine the relationship between coronary artery disease polygenic risk scores that include variants below thresholds of genome-wide significance and statin primary prevention of major adverse cardiovascular events.

Methods

We generated coronary artery disease polygenic risk scores for participants with no past evidence of myocardial infarction from three electronic health record-linked genetic biobanks: All of Us Research Program, Genetic Epidemiology Research on Adult Health and Aging, and the Million Veteran Program. We scored each participant using three different polygenic risk scores: two with both ge

SUBMITTER: Haldar T 

PROVIDER: S-EPMC12633136 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature