Type 2 Diabetes Remission: A Systematic Review and Meta-analysis of Nonsurgical Randomized Controlled Trials.

ABSTRACT:

Background

Evidence that type 2 diabetes can be reversed has been limited by the understanding and implementation of these interventions.

Purpose

We assessed the effect of nonsurgical randomized controlled trials (RCTs) on type 2 diabetes remission and characterized core components.

Data sources

We reviewed articles from MEDLINE and Embase (inception to April 2025).

Study selection

RCTs of multimodal pharmacological or nonpharmacological type 2 diabetes remission interventions for adults with type 2 diabetes were included.

Data extraction

Study characteristics and outcomes for clinical/population health, patient-reported, and adverse event were extracted.

Data synthesis

We performed a random-effects multilevel meta-analysis of studies, grouped bas

SUBMITTER: Sherifali DT 

PROVIDER: S-EPMC12635883 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature