Microengineered patient-derived endometrium-on-a-chip for the evaluation of endometrial receptivity and personalised translational medicine.

ABSTRACT: Endometrial receptivity is a critical determinant of embryo implantation and early pregnancy success; however, current methods for assessing endometrial receptivity remain poorly validated and insufficiently reliable for clinical application. Here, we establish a patient-derived vascularised endometrium-on-a-chip (EoC), successfully replicating the dynamic microenvironment and both temporal and spatial architecture of native endometrial tissue. Using our EoC, we develop a clinically relevant endometrial receptivity scoring system, ERS², which integrates molecular profiling of established receptivity markers with quantitative analyses of angiogenesis. The ERS² enables personalised assessment of endometrial health and implantation potential, addressing inter-patient var

SUBMITTER: Lee G 

PROVIDER: S-EPMC12647634 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature