Protective Anti-Inflammatory and Antioxidant Mechanisms of <i>Ohwia caudata</i> Leaf Hydroethanolic Extract in a Dermatitis Mouse Model.

ABSTRACT: Contact dermatitis is a common inflammatory skin disorder characterized by erythematous and pruritic lesions caused by irritant exposure. Ohwia caudata, a traditional medicinal plant, possesses anti-inflammatory and antioxidant properties, but its dermatoprotective potential remains unclear. To investigate the protective effects and mechanisms of Ohwia caudata leaves' hydroethanolic extract in a murine model of TPA-induced contact dermatitis. Major phytochemicals in Ohwia caudata extract were identified by HPLC-MS. SKH1/J hairless mice were topically treated with Ohwia caudata extract following TPA stimulation. Skin barrier function was assessed by transepidermal water loss and hydration. Inflammatory (IL-6, TNF-α, TGF-β), antioxidant (SIRT1, Nrf2, HO-1), and ER

SUBMITTER: Lin TK 

PROVIDER: S-EPMC12653036 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature