Co(II)-Catalyzed Picolinamide-Directed C(sp³)-S Bond Formation with <i>N</i>-(phenylsulfanyl)succinimides.

ABSTRACT: Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp³)-H bond formation with N-(phenylsulfanyl)succinimides. This method enables the direct construction of C(sp³)-S bonds under mild conditions and exhibits excellent functional group tolerance along with a broad substrate scope. Notably, the catalytic system achieves oxidative C-H functionalization without relying on costly or environmentally detrimental oxidants, offering a more sustainable and practical alternative for C-S bond formation.

SUBMITTER: Qin J 

PROVIDER: S-EPMC12655464 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature