A comprehensive analysis of B symptoms reveals prognosis and heterogeneity across different sites of diffuse large B-cell lymphoma.

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive form of non-Hodgkin lymphoma. B symptoms, including fever, night sweats and weight loss, are often overlooked but carry prognostic significance. The primary site of DLBCL also plays a crucial role in diagnosis and treatment decisions, and our study aims to explore the relationship among primary sites of DLBCL, the presence of B symptoms and patients' survival. 15,267 patients' data were analyzed in our study to investigate the potential relevance among B symptoms, primary sites and patients' survival. We assessed the influence of primary site and B symptoms on survival with the use of Survival package and Kaplan-Meier survival analysis. Age, race and Ann-Arbor stage were significantly associated with the presence of B symptoms. T

SUBMITTER: Wu C 

PROVIDER: S-EPMC12672776 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature