Dorsal hippocampus mediates light-tone associations in male mice.

ABSTRACT: Daily choices are often influenced by environmental cues that are not directly associated with reinforcers. This phenomenon, known as higher-order conditioning, can be studied using sensory preconditioning tasks in rodents. This behavioral paradigm involves the repeated pairing of two innocuous stimuli, such as a light and a tone, followed by a devaluation phase in which one stimulus is associated with an unconditioned stimulus, such as a mild footshock. The result is a conditioned response (e.g., freezing) to both the conditioned stimulus (direct learning) and the non-conditioned stimulus (mediated learning). In our study, we successfully established a light-tone sensory preconditioning task specifically in male mice, as sex differences were observed in both control experimental groups an

SUBMITTER: Pinho JS 

PROVIDER: S-EPMC12674615 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature