Robust adhesion between solid-state hydroxyapatite and bone tissue through surface demineralization.

ABSTRACT:

Objective

Current bone adhesives typically lack adequate mechanical strength, long-term stability, or biocompatibility. To address these limitations, we designed a new adhesion strategy using a solid-state hydroxyapatite (HAp) adhesive in combination with bone surface demineralization.

Methods

Solid-state HAp adhesives were synthesized via wet chemical precipitation and heat treatment. Cortical bone specimens were partially demineralized with phosphoric acid (H₃PO₄) or ethylenediaminetetraacetic acid (EDTA), and characterized using scanning electron microscopy (SEM) and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). Shear adhesion strength of HAp to demineralized bone was measured over time. In vivo fixation was

SUBMITTER: Xie S 

PROVIDER: S-EPMC12686729 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature