Osteocalcin and frailty among older women.

ABSTRACT:

Background

Osteocalcin is a bone-specific protein involving many physiological processes, primarily bone turnover. Also closely related to the musculoskeletal system is the frailty syndrome.

Aim

To investigate if circulating osteocalcin levels and frailty are associated in the old, and in addition, if the presumed association is mediated through alterations in bone.

Methods

999 community-dwelling women from the OPRA (Osteoporosis Prospective Risk Assessment) cohort, all aged 75 years. Serum total osteocalcin was measured together with bone turnover markers PINP and CTX. An OPRA-adapted frailty index was applied. Association between osteocalcin and frailty was investigated using both logistic regression (osteocalcin quintiles Q_low-Q_high; Q_1</

SUBMITTER: Paulin TK 

PROVIDER: S-EPMC12689723 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature