20 Hz beta stimulation of the subthalamic nucleus improves response inhibition in Parkinson's disease.

ABSTRACT: High-frequency deep brain stimulation of the subthalamic nucleus is used to treat motor symptoms in patients with Parkinson's disease. There is evidence that low-frequency stimulation in the range of 4-10 Hz may improve cognitive functions. This study investigates whether low-frequency deep brain stimulation of the subthalamic nucleus in the beta band (20 Hz) frequency can improve response inhibition in patients with Parkinson's disease. In a double-blind crossover design, N = 17 participants with Parkinson's disease performed four neuropsychological experiments, while on their usual dopaminergic medication, under no, standard high-frequency and 20 Hz beta low-frequency deep brain stimulation. The experiments consisted of a response selection task (response execution), a flanker tas

SUBMITTER: Kricheldorff J 

PROVIDER: S-EPMC12690201 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature