Multi-omics techniques revealing the mechanism of <i>Polygonatum sibiricum</i> Huangjiu in alleviating hyperlipidemia in mice.

ABSTRACT:

Introduction

Hyperlipidemia poses a serious threat to human health. However, given the significant adverse effect of drug therapy, finding safe and efficient lipid-lowering agents has become a focal point of interest. Polygonatum sibiricum Huangjiu (PSHJ) is hypothesized to exert lipid-lowering effects. This study examined PSHJ's ability to alleviate hyperlipidemia in mice caused by a high-fat diet, and the regulatory mechanism was studied via gut microbiome and fecal lipidomics.

Methods

A mouse model of hyperlipidemia was established using a high-fat diet. The experimental groups were administered PSHJ, and serum lipid profiles-including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (

SUBMITTER: Geng J 

PROVIDER: S-EPMC12695534 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature