Establishing Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory.

ABSTRACT:

Background

Promising developments in Pb-212 radiopharmaceutical therapies have increased demand for Pb-203 diagnostic agents. Building on previous work from various isotope production facilities, this study optimized Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory (BNL). The additional supply of Pb-203 may help meet growing preclinical and clinical demands.

Results

Two Tl targets were irradiated at the Brookhaven Linac Isotope Producer facility with 30 ± 1 MeV protons, measured using previously published cross section data. Distribution coefficients for Pb Resin in acetate media were investigated for both Na⁺ and K⁺ cations, where potassium acetate was ~ 4 times more effective at stripping Pb from the Pb Resin. The T

SUBMITTER: Lin W 

PROVIDER: S-EPMC12696209 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature