Plasma-derived exosomal miRNAs as potentially novel biomarkers for type 2 diabetes mellitus with abdominal obesity.

ABSTRACT:

Aims

To explore the plasma exosomal miRNA expression profiles in patients with abdominal obesity and type 2 diabetes mellitus (T2DM), identify differentially expressed exosomal m4RNAs, and evaluate the potential of selected exosomal miRNAs as biomarkers for abdominal obesity-related T2DM.

Methods

In the screening phase, high-throughput sequencing was used to detect the plasma exosomal miRNA expression profiles of non-abdominal obese individuals with normal glucose metabolism (NAO/NG, N = 4), abdominal obese individuals with normal glucose metabolism (AO/NG, N = 4), and abdominal obese T2DM patients (AO/T2DM, N = 4). Five differentially expressed miRNAs were identified. In the independent validation phase, RT-qPCR was performed to validate the expression of these miRNAs in th

SUBMITTER: Li Y 

PROVIDER: S-EPMC12698432 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature